Staudinger ligation: a peptide from a thioester and azide |
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Authors: | Nilsson B L Kiessling L L Raines R T |
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Affiliation: | Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. |
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Abstract: | [reaction: see text] The technique of native chemical ligation enables the total chemical synthesis of proteins. This method is limited, however, by an absolute requirement for a cysteine residue at the ligation juncture. Here, this restriction is overcome with a new chemical ligation method in which a phosphinobenzenethiol is used to link a thioester and azide. The product is an amide with no residual atoms. |
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