| 稀土掺杂上转换纳米粒子的表面功能化修饰及其生物应用 |
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| 引用本文： | 白安琪,彭孔浩,孟 颖,殷 慧,宿欣瑶,罗利霞,张凌燕,李淑荣,孟佩俊. 稀土掺杂上转换纳米粒子的表面功能化修饰及其生物应用[J]. 化学通报, 2024, 87(4): 427-435 |
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| 作者姓名： | 白安琪 彭孔浩 孟 颖 殷 慧 宿欣瑶 罗利霞 张凌燕 李淑荣 孟佩俊 |
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| 作者单位： | 内蒙古科技大学包头医学院公共卫生学院,内蒙古科技大学包头医学院公共卫生学院,内蒙古科技大学包头医学院公共卫生学院,内蒙古科技大学包头医学院公共卫生学院,内蒙古科技大学包头医学院公共卫生学院,内蒙古科技大学包头医学院公共卫生学院,内蒙古科技大学包头医学院公共卫生学院,内蒙古科技大学包头医学院公共卫生学院,内蒙古科技大学包头医学院公共卫生学院 |
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| 基金项目： | 国家自然科学基金项目(81960601,82360656)、内蒙古自治区高等学校青年科技英才支持项目(NJYT23026)、内蒙古自治区自然科学基金项目(2023MS08009,2021MS08055)、内蒙古自治区卫生健康委医疗卫生科技计划项目(202201383)、包头医学院2023年研究生科研创新项目(bycx2023006)和2023年自治区级大学生创新创业训练计划项目(S202310130001)资助 |
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| 摘 要： | 稀土掺杂上转换纳米粒子(RED-UCNPs)作为一种新型高效的上转换发光纳米材料，具有反斯托克斯位移大，发射光谱窄、发光寿命长、材料毒性低等优点，已成为荧光标记、光动力学治疗、生物成像和构建生物传感器等领域的研究热点。然而，目前广泛使用的溶剂热法合成的RED-UCNPs生物相容性和亲水性差，而且不具备与生物分子之间相偶联的活性基团，因此对RED-UCNPs进行表面功能化修饰就显得格外重要。本文重点综述了RED-UCNPs的表面功能化修饰的类型及其应用现状，为RED-UCNPs的进一步研究开发和应用提供思路和参考依据。
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| 关 键 词： | 稀土掺杂上转换纳米粒子 表面功能化修饰 生物应用 |
| 收稿时间： | 2023-10-18 |
| 修稿时间： | 2023-11-08 |
Surface functionalization modification of Rare-earth-elements-doped upconversion nanoparticles and its application |
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| Bai Anqi,Peng Konghao,Meng Ying,Yin Hui,Su Xinyao,Luo Lixi,Zhang Lingyan,Li Shurong and Meng Peijun. Surface functionalization modification of Rare-earth-elements-doped upconversion nanoparticles and its application[J]. Chemistry, 2024, 87(4): 427-435 |
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| Authors: | Bai Anqi Peng Konghao Meng Ying Yin Hui Su Xinyao Luo Lixi Zhang Lingyan Li Shurong Meng Peijun |
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| Affiliation: | Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology,Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology,Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology,Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology,Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology,Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology,Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology,Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology,Public Health School,Baotou Medical College,Inner Mongolia University of Science and Technology |
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| Abstract: | Rare-earth-elements-doped upconversion nanoparticles (RED-UCNPs), as a new and efficient up-conversion luminescent nanomaterials, have the advantages of large anti-Stokes shift, narrow emission spectrum, long luminescent lifetime and low material toxicity, and have become a research hotspot in the fields of fluorescence labeling, photodynamic therapy, bioimaging and biosensor construction. However, the widely used solvothermal synthesis of RED-UCNPs has poor biocompatibility and hydrophilicity, and does not have the active group coupled with biological molecules, so it is particularly important to modify the surface functionalization of RED-UCNPs. In this paper, the types of RED-UCNPssurface functionalization and its application status are reviewed, which provides ideas and references for further research, development and application of RED-UCNPs. |
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| Keywords: | Rare-earth-elements-doped upconversion nanoparticles Surface functional modification Applications |
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