高压静电法制备多孔磁性壳聚糖微球

以壳聚糖(Chitosan, CS)为基质, 通过共混法引入四氧化三铁磁性颗粒, 以硅胶(Silicagel, S)为致孔剂, 在热的NaOH溶液中溶出硅胶致孔, 采用高压静电法制备磁性壳聚糖微球. 通过SEM观察了微球的结构和形貌, 并对微球结构和形貌的影响因素及其制备工艺进行了系统的研究, 结果表明, 高压静电法制备的磁性硅胶/壳聚糖微球粒径可通过微量进样器的针头大小来控制, 并且粒径分布均匀, 实验重复性及可控性好; 当以质量体积分数为5%的壳聚糖醋酸溶液(体积分数2％, mS∶mCS=4∶1), 用8号针头进样时, 制得直径约为600 μm, 孔洞分布均匀, 孔径约为50 μm的多孔磁性壳聚糖微球. 由于磁性多孔壳聚糖微球中含有大量的活性羟基和氨基, 因此显弱碱性, 对酸性物质和金属离子的吸附作用很好, 且可通过外加磁场进行有效分离. 磁性多孔壳聚糖微球在生物分离及污水中的酸性染料处理方面具有潜在的应用价值.

Preparation of Porous Magnetic Chitosan Microsphere via High Voltage Electrostatic Method

Porous magnetic chitosan microspheres with average diameter about 600 μm were prepared by high voltage electrostatic method through mixing Fe3O4 particles into CS with silicagel as pore-forming agent and then adding them into thermal NaOH solution to get porous structure. This research studied the preparation technology , as well as the structure and morphology of microsphere with SEM, the results of which indicate that holes of porous magnetic chitosan microspheres with the size approximately 50 μm were uniformly dispersed in the microsphere when the mass volume fraction of chitosan acetic acid aqueous solution was 5% and mS∶mCS was 4∶1. Due to its large amount of hydroxyl groups and amino groups, porous magnetic chitosan microspheres could be widely used to deal with acidic dyestuff to improve environment and separated from dirty water by adding magnetic field.