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One-pot five-component synthesis of highly functionalized piperidines using oxalic acid dihydrate as a homogenous catalyst |
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| Authors: | Seyed Sajad Sajadikhaha Malek Taher Maghsoodloua Nourallah Hazeria Sayyed Mostafa Habibi-Khorassania Anthony CWillisb a |
| Institution: | Department of Chemistry, The University of Sistan and Baluchestan, P.O.Box 98135-674, Zahedan, Iran ; Research School of Chemistry, The Australian National University, Canberra, ACT 0200, Australia |
| Abstract: | An efficient green protocol is described for the preparation of highly functionalized piperidines via a one-pot five-component reaction between aromatic aldehydes,anilines andβ-ketoesters in the presence of oxalic acid dihydrate as catalyst in ethanol at ambient temperature.The structure as well as the relative stereochemistry of these compounds was confirmed by single X-ray crystallographic analysis. |
| Keywords: | Piperidine Heterocycle Homogeneous catalyst Oxalic acid dihydrate Multi-component reaction |
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