A general route to unsubstituted N-aryl and heteroarylaminobenzenesulfonamides |
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| Authors: | Franck Lach,Marie-Jeanne PasquetMylè ne Chabanne |
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| Affiliation: | a AstraZeneca, Centre de Recherches, Z.I. la Pompelle, BP 1050, 51689 Reims Cedex 2, France
b Université de Nantes, UMR 6230 CEISAM CNRS, 2, rue de la Houssinnière, 44322 NANTES Cedex 3, France |
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| Abstract: | Starting from suitably protected 3- and 4-aminobenzenesulfonamides, a practical two-step strategy for the synthesis of unsubstituted N-aryl and heteroarylaminobenzenesulfonamides was devised. Strong bases are tolerated during the N-arylation step. Overall moderate to excellent yields are reported. |
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| Keywords: | Buchwald-Hartwig coupling Sulfonamide Paramethoxybenzyl Protecting group |
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