Facile and efficient synthesis of quinolin-2(1H)-ones via cyclization of penta-2,4-dienamides mediated by H2SO4 |
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| Authors: | Liu Xu Xin Xin Xiang Dexuan Zhang Rui Kumar Santosh Zhou Fenguo Dong Dewen |
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| Affiliation: | Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. |
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| Abstract: | A facile and efficient synthesis of substituted quinolin-2(1H)-ones is developed via intramolecular cyclization of penta-2,4-dienamides mediated by concentrated H(2)SO(4) (98%), and a mechanism involving the formation of a dicationic superelectrophile, and subsequent intramolecular nucleophilic cyclization reactions is proposed. |
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