One-pot multistep synthesis of 4-acetoxy-2-amino-3-arylbenzofurans from 1-aryl-2-nitroethylenes and cyclohexane-1,3-diones |
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| Authors: | Ishikawa Teruhiko Miyahara Tadashi Asakura Mami Higuchi Shuichi Miyauchi Yayoi Saito Seiki |
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| Institution: | School of Education, Okayama University, Tsushima, Okayama, 700-8530, Japan. teruhiko@cc.ikayama-u.ac.jp |
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| Abstract: | reaction: see text] A novel method for synthesizing 4-acetoxy-2-amino-3-arylbenzofurans (4) from 1-aryl-2-nitroethylenes (1) and cyclohexane-1,3-diones (2) is described. The method features one-pot operation of a solution of 1 and 2 in THF with catalytic Et3N (rt, 12 h) followed with Ac2O, Et3N, and DMAP (rt, 5 h), although the process consists of 13 elementary reactions. |
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