Midkine,heparin-binding growth factor,blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus |
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| Authors: | Yun B Kim Jae K Ryu Hong J Lee In J Lim Dongsun Park Min C Lee and Seung U Kim |
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| Institution: | (1) Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, Canada;(2) College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea;(3) Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea;(4) Department of Physiology, Chung-Ang University College of Medicine, Seoul, Korea;(5) Department of Pathology, Chonnam National University Medical School, Gwangju, Korea |
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| Abstract: | Background Midkine (MK), a member of the heparin-binding growth factor family, which includes MK and pleiotrophin, is known to possess
neurotrophic and neuroprotective properties in the central nervous system. Previous studies have shown that MK is an effective
neuroprotective agent in reducing retinal degeneration caused by excessive light and decreasing hippocampal neuronal death
in ischemic gerbil brain. The present study was undertaken to investigate whether MK acts as an anticonvulsant in kainic acid
(KA)-induced seizure in mouse and blocks KA-mediated neuronal cell death in hippocampus. |
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