<Emphasis Type="Italic">tert</Emphasis>-Butyl (2<Emphasis Type="Italic">S</Emphasis>)-(<Emphasis Type="Italic">p</Emphasis>-tolylsulfonyloxy)propionate — a suitable reagent for the direct alkylation of indole derivatives |
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Authors: | A V Kurkin D S Belov M A Yurovskaya |
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Institution: | (1) M. V. Lomonosov Moscow State University, Moscow, 119992, Russia |
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Abstract: | A new method is proposed for the synthesis of indole derivatives containing a chiral substituent at the nitrogen atom, which
includes the direct alkylation of indole derivatives with tert-butyl (2S)-(p-tolylsulfonyloxy)propionate, obtained from commercial
ethyl (S)-lactate with subsequent conversion to the corresponding p-toluenesulfonyloxy derivative by hydrolysis, and esterification.
Dedicated to Academician B. A. Trofimov on his 70th birthday.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, 1391–1398, September, 2008. |
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Keywords: | tert-butyl (2S)-(p-tolylsulfonyloxy)propionate isatins nonracemic N-substituted indoles 1 2 3 4-tetrahydrocarbazoles and γ -carbolines ethyl (S)-lactate |
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