Synthesis and antibacterial activities of pleuromutilin derivatives |
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| Authors: | Yuan Yuan Zhanga Ke Ping Xub Dan Renc Shao Rong Gec Yu Liang Wang Yu Zhong Wang a |
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| Institution: | a Department of Chemical Engineering, Sichuan University, Chengdu 610065, China;b Department of Chemistry, Sichuan University, Chengdu 610064, China;c Department of Life Science, Sichuan University, Chengdu 610064, China |
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| Abstract: | Six new pleuromutilin derivatives were designed and synthesized, confirmed by MS, IR and 1H NMR techniques. And the antibacterial activities were primarily evaluated in vitro. The results indicated that most of the derivatives showed more potent activities against corresponding bacterial strains than that of pleuromutilin. Especially, compounds 4d and 5b had obvious activities against salmonella compared with pleuromutifin. |
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| Keywords: | Pleuromutilin Derivatives Synthesis Antibacterial activities |
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