| 邻氯苯甲腈的新合成法 |
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| 引用本文： | 朱益忠,张喜全,刘飞,顾红梅,朱海亮. 邻氯苯甲腈的新合成法[J]. 应用化学, 2013, 30(8): 971-973. DOI: 10.3724/SP.J.1095.2013.20530 |
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| 作者姓名： | 朱益忠 张喜全 刘飞 顾红梅 朱海亮 |
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| 作者单位： | (1.江苏正大天晴药业股份有限公司 南京 210042；2.南京大学生命科学学院医药生物技术国家重点实验室 南京 210093) |
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| 摘 要： | 以邻氯溴苯为起始原料,选用K4[Fe(CN)6]为氰基化试剂，Pd/C催化反应制得邻氯苯甲腈。 考察了温度、碱、催化剂的用量和原料比等对反应的影响，确定了较佳反应条件。 邻氯溴苯转化率达98.5%，产物邻氯苯甲腈得率95.1%。
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| 关 键 词： | 邻氯溴苯 K4[Fe(CN)6] 氰基化反应 |
| 收稿时间： | 2012-11-16 |
| 修稿时间： | 2013-01-29 |
A New Synthetic Route Toward o-Chlorobenzonitrile |
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| ZHU Yizhong , ZHANG Xiquan , LIU Fei , GU Hongmei , ZHU Hailiang. A New Synthetic Route Toward o-Chlorobenzonitrile[J]. Chinese Journal of Applied Chemistry, 2013, 30(8): 971-973. DOI: 10.3724/SP.J.1095.2013.20530 |
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| Authors: | ZHU Yizhong ZHANG Xiquan LIU Fei GU Hongmei ZHU Hailiang |
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| Affiliation: | (1.Jiangsu Chiatai Tianqing Pharmaceutical Co. Ltd.,Nanjing 210042,China;2.State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing 210093,China) |
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| Abstract: | o-Chlorobenzonitrile was prepared from the cyanization reaction of o-chlorobromobenzene using potassium ferrocyanide as cyanating agent and Pd/C as a catalyst. The reaction conditions were optimized through investigating the reaction temperature, base, the amount of catalyst, the ratio of reactants. The conversion of the o-chlorobromobenzene to target product could reach 98.5% and the yield of o-chlorobenzonitrile was 95.1%. |
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| Keywords: | o-chlorobromobenzene potassium ferrocyanide cyanization reaction |
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