Synthesis of Thiazole and Fused Thiazolo Derivatives |
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Authors: | Uro Urleb Richard Neidlein Walter Kramer |
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Institution: | Uro? Urleb,Richard Neidlein,Walter Kramer |
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Abstract: | The syntheses of thiazole and fused thiazolo derivatives 2 – 4 , 6 – 8 , 10a – 11b , 13 – 16 from heterocylic isothiocyanates 1 , 5 , 9 , and 12 bearing an ortho ester group and bifunctional reagents, such as substituted propargylamines, is described. Different regioselectivity of intramolecular nucleophilic attack of the thiourea S-atom on the C ? C bond, resulting in the formation of both thiazolo and thiazino derivatives, as well as NMR structure elucidation are discussed. |
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