| Abstract: | Four heterocyclic amines including 1,2-diethyl-3-aminomethylpyrazolidine ( 3 ), 1-(2-aminoethyl)-2-methyl-pyrazolidine ( 5 ), 1,2-dimethyl-4-aminomethylpyrazolidine ( 7 ), and 1,2-diethyl-4-aminopyrazolidine ( 9 ) have been synthesized. Each was acylated with p-nitrobenzoyl chloride and afforded the corresponding p-nitro-benzamides 10, 12, 14 , and 16. Catalytic reduction of these nitro intermediates gave the corresponding p-aminobenzamides 11,13,15 , and 17 . The latter compounds are analogs of procainamide and two of them, 15 and 17 , were evaluated in the isolated cardiac Purkinje fiber preparation by measuring their effects on the action potential upstroke velocity. |
