Synthesis of 3-(β-D-ribofuranosyl)pyrazolo[3,2-i]-purine derivatives and their cytotoxic activities |
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Authors: | Norimitsu Hamamichi Tadashi Miyasaka |
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Abstract: | 9-Amino-3-(β-D-ribofuranosyl)pyrazolo3,2-i|purine ( 6 ) has been prepared from a fully protected 3-(β-D-ribofuranosyl)pyrazolo3,2-i]purine ( 2 ) and the 9-bromo substituted derivative 3 by nitration, followed by reduction. Reaction of 9-bromo-3-(β-D-ribofuranosyl)pyrazolo3,2-i)purine ( 1b ) with alkali gave the (pyrazol-3-yl)imidazole derivative, followed by diazocyclization with sodium nitrate to give 9-bromo-3-(β-D-ribofuran-osyl)imidazolo4,5-d]pyrazolo2,3-c]1,2,3]triazine ( 10 ) after deacetylation. Compounds 6 and 10 exhibited cytotoxic activity against leukemia cells. |
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