Photosensitized oxidation of tryptophan and tyrosine by aromatic ketones: A laser flash photolysis study |
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| Authors: | RuiZhi Tang Peng Zhang HaiXia Li YanCheng Liu WenFeng Wang |
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| Affiliation: | 1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China
2. Graduate University of Chinese Academy of Sciences, Beijing, 100049, China
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| Abstract: | Photochemical processes of benzophenone (BP) and xanthone (XT) with tryptophan (TrpH) and tyrosine (TyrOH) were studied using the laser flash photolysis technique. It has been observed that the triplet state of BP and XT reacted with TrpH and TyrOH by hydrogen transfer with the formation of BP and XT ketyl radicals and oxidized radicals of Trp· and TyrO·. The related rate constants of these reactions were determined in this paper. The free energy changes (??G) of these reactions suggested that the proposed hydrogen transfer mechanism was thermodynamically feasible. These results provide theoretical foundation for further studying structural effects on the photochemical behaviors of proteins with triplet state BP and XT. |
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| Keywords: | benzophenone xanthone tryptophan tyrosine laser flash photolysis |
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