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PHOTOCHEMISTRY OF 4-THIOURIDINE AND THYMINE |
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| Authors: | Meyrick J Peak W Robert Midden David M Babasick David A Haugen |
| Institution: | Molecular Photobiology Group, Division of Biological and Medical Research, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439–4833, USA;Center for Photochemical Sciences, Department of Chemistry, Bowling Green State University, Bowling Green, OH 43403, USA;Chemical and Biological Characterization Group, Division of Biological and Medical Research, Argonne National Laboratory, Argonne, IL 60439–4833, USA |
| Abstract: | Abstract— When thymine is irradiated in aqueous solution with monochromatic 334-nm UV radiation in the presence of 4-thiouridine a photoproduct of thymine is formed, as shown by thin-layer chromatography and autoradiography. The quantum yield for the formation of thymine photoproduct (θ=0.017) is greater than that for cytosine photoproduct formation (θ= 0.0015). The identity of the photoproduct is not known: one possibility is the formation of an adduct between the sensitizer and the base yielding a pyrimidine-pyrimidone type of photoproduct. |
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