| 吩噻嗪类药物的流动注射在线氧化荧光分析法测定 |
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| 引用本文： | 马红燕,高瑞,罗娟娟,杨猛. 吩噻嗪类药物的流动注射在线氧化荧光分析法测定[J]. 分析测试学报, 2010, 29(4). DOI: 10.3969/j.issn.1004-4957.2010.04.009 |
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| 作者姓名： | 马红燕 高瑞 罗娟娟 杨猛 |
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| 作者单位： | 延安大学,化学与化工学院,分析化学研究所,陕西,延安,716000;延安大学,化学与化工学院,分析化学研究所,陕西,延安,716000;延安大学,化学与化工学院,分析化学研究所,陕西,延安,716000;延安大学,化学与化工学院,分析化学研究所,陕西,延安,716000 |
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| 基金项目： | 陕西省教育厅专项科研基金,延安市科技局科技计划资助项目 |
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| 摘 要： | 结合流动注射进样技术,借助时间扫描荧光方式,建立了流动注射在线氧化荧光分析法测定吩噻嗪类药物的新方法。在优化的实验条件下,盐酸氯丙嗪、奋乃静、盐酸异丙嗪的质量浓度分别在0.12~36、0.4~20、0.4~36 mg/L范围内与荧光强度呈良好的线性关系,方法检出限分别为0.003 6、0.02、0.03 mg/L。该方法简便、快速、准确、灵敏度高,用于药物制剂、尿样中吩噻嗪类药物的直接测定,结果满意。
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| 关 键 词： | 吩噻嗪类药物 流动注射分析 在线氧化 荧光光度法 |
Determination of Phenothiazines Drugs by Flow Injection On-line Oxidizing Fluorophotometric Method |
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| MA Hong-yan,GAO Rui,LUO Juan-juan,YANG Meng. Determination of Phenothiazines Drugs by Flow Injection On-line Oxidizing Fluorophotometric Method[J]. Journal of Instrumental Analysis, 2010, 29(4). DOI: 10.3969/j.issn.1004-4957.2010.04.009 |
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| Authors: | MA Hong-yan GAO Rui LUO Juan-juan YANG Meng |
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| Affiliation: | MA Hong-yan,GAO Rui,LUO Juan-juan,YANG Meng(Institute of Analytical Chemistry,College of Chemistry , Chemical Engineering,Yan'an University,Yan'an 716000,China) |
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| Abstract: | A novel fluorescent system coupled with flow injection technique was developed for the determination of three phenothiazine drugs,e.g.chlorpromazine hydrochloride,perphenazine and promethazine hydrochloride.The experiments indicated that the fluorescence signal of three drugs was weak.But the fluorescence intensities of three drugs could be sensitized strongly in the prescence of KMnO4 oxidant.Based on this,a new on-line oxidizing fluorescent method combined with flow injection technique was established for... |
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| Keywords: | phenothiazines drugs flow injection analysis on-line oxidizing fluorophotometry |
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