Utilization of Supercritical Carbon Dioxide for the Preparation of 3-Hydroxyflavone and β-Cyclodextrin Complex |
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| Authors: | Bo Wang Jun He Donghai Sun Rui Zhang Buxing Han |
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| Affiliation: | (1) Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, 100080 Beijing, China |
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| Abstract: | The solubility of 3-hydroxyflavone in water can be enhanced by forming complex with β-cyclodextrin (β-CD). In this study we introduced supercritical carbon dioxide as a substitute solvent to prepare 3-hydroxyflavone-β-cyclodextrin complex. The maximum drug loading determined by UV spectroscopy in complex was 14.7 wt.%, which was comparable to that of 1:1 complex (17.34 wt.% of 3-hydroxyflavone). The solubility of the drug loaded in the complex was better than that of pure drug in water. The enhanced solubility was attributed to the formation of the complex and the solubility of the β-cyclodextrin in water. |
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| Keywords: | β -cyclodextrin inclusion complex 3-hydroxyflavone supercritical carbon dioxide |
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