The Allylic Alkylation of Ketone Enolates |
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Authors: | Dr Lukas Junk Prof Dr Uli Kazmaier |
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Institution: | Organic Chemistry I, Saarland University, Campus C4.2, 66123 Saarbrücken, Germany |
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Abstract: | The palladium-catalyzed allylic alkylation of non-stabilized ketone enolates was thought for a long time to be not as efficient as the analogous reactions of stabilized enolates, e. g. of malonates and β-ketoesters. The field has experienced a rapid development during the last two decades, with a range of new, highly efficient protocols evolved. In this review, the early developments as well as current methods and applications of palladium-catalyzed ketone enolate allylations will be discussed. |
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Keywords: | allylic alkylations enolates ketones palladium transition metals |
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