Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes |
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| Authors: | Ryo Sasaki Dr. Kohei Sato Prof. Kazushi Kinbara |
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| Affiliation: | School of Life Science and Technology, Tokyo Institute of Technology 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8501 Japan |
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| Abstract: | We designed multiblock amphiphiles AmF and AmH , which consist of perfluorinated and non-fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether AmF and AmH can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of AmF that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of AmH . |
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| Keywords: | aromatic fluorination lipid bilayer membranes multiblock amphiphiles self-assembly supramolecular chemistry |
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