Investigation of Parameters that Affect Resin Swelling in Green Solvents |
| |
Authors: | Chidi Amadi-Kamalu Holly Clarke Matthew McRobie James Mortimer Prof Michael North Yanrui Ran Dr Anne Routledge Dani Sibbald Matthew Tickias Kai Tse Helen Willway |
| |
Institution: | Department of Chemistry, University of York, York, UK, YO10 5DD |
| |
Abstract: | The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis. |
| |
Keywords: | polystyrene solvent swelling ChemMatrix peptide |
|