Fluorescent cyclodextrins bearing metal binding sites and their use for chemo- and enantioselective sensing of amino acid derivatives |
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Authors: | Roberto Corradini Cristina Paganuzzi Rosangela Marchelli Sara Pagliari Arnaldo Dossena Alexander Duchateau |
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Affiliation: | (1) Dipartimento di Chimica Organica e Industriale, Università di Parma Parco Area delle Scienze, Viale G.P. Usberti 17/A, 43100 Parma, Italy;(2) DSM Research, P.O. Box 18, 6160, MD, Geleen, The Netherlands;(3) Present address: Callegari S.p.A., Via Adamello 2/A, 43100 Parma, Italy |
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Abstract: | Ditopic receptors based on cyclodextrins bearing a metal binding site were used as enantioselective fluorescence sensors, which were able to generate different responses in the presence of d- or l-amino acids. The performances of the selectors as a function of their structure were evaluated, and the same analysis was extended to other analytes. In this work, this approach is used for the enantiomers of a series of amino acid derivatives and in particular of 2-aminocaprolactam. The results showed that the ability of these sensors to perform enantiomeric analysis can be extended to other analytes of interest in organic synthesis such as amino acid amides and α-aminolactams. |
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Keywords: | Fluorescent sensors Enantioselectivity Amino acids derivatives Cyclodextrins |
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