Design, syntheses and biological activity of novel ALS inhibitors (IX) |
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Authors: | Guangfu Yang Huayin Liu Xiufeng Yang Huazheng Yang |
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Institution: | (1) State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, 300071 Tianjin, China |
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Abstract: | Quantitative structure-activity relationships for herbicidal activity against rape of sulfonylurea and triazolopyrimidine-2-sulfonamide
derivatives were examined three-dimensionally using comparative molecular field analysis (CoMFA). The CoMFA results show that
the slopes in steric and electrostatic fields around the molecule were significant for both series in governing the potency
variations in herbicidal activity. Based upon the successful superposition between the two series, the herbicidal activity
was analyzable with a single equation for the combined set of compounds, which suggested that the two different series of
compounds have a common region of the receptor site.
Project supported by the National Natural Science Foundation of China (Grant No. 29832050), the Special Key Fund of Natural
Science of Tianjin (Grant No. 983801011) and the Doctoral Fund of the Education Ministry of China. |
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Keywords: | acteolactate synthase inhibitors comparative molecular field analysis CoMFA structure-activity relationships pharmacophore sulfonylurea triazolopyrimidine-2-sulfonamide |
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