| PVP/Pd/IrO_2/Nafion修饰微电极用于成纤维细胞中一氧化氮释放的研究 |
| |
| 引用本文： | 鲜跃仲,徐继明,陆嘉星,刘梅川,蔡琪,金利通. PVP/Pd/IrO_2/Nafion修饰微电极用于成纤维细胞中一氧化氮释放的研究[J]. 化学学报, 2002, 60(8): 1459-1464 |
| |
| 作者姓名： | 鲜跃仲 徐继明 陆嘉星 刘梅川 蔡琪 金利通 |
| |
| 作者单位： | 华东师范大学化学系.上海(200062) |
| |
| 基金项目： | 国家自然科学基金 (No .2 9975 0 0 9)，上海市自然科学基金 (No .0 0ZA14 0 11)资助项目 |
| |
| 摘 要： | 采用PVP/Pd/IrO_2/Nafion修饰电极对成纤维细胞中NO的释放情况进行了研究 。结果表明，在正常状态下，采用NO前体L-精氨酸和乙酰胆碱对成纤维细胞进行刺 激后没有NO的释放；当用脂多糖进行诱导后，则释放出高浓度的NO，加入L-精氨酸 和乙酰胆碱都促进了NO的合成，而L-NNA的加入则逆转了L-精氨酸和乙酰胆碱的作 用。
|
| 关 键 词： | 钯 氧化铱 化学修饰电极 一氧化氮 精氨酸 乙酰胆碱 |
| 修稿时间： | 2001-12-24 |
Direct Monitoring of Nitric Oxide Release from Fibrocytes with PVP/Pd/IrO_2/Nation Chemically Modified Microelectrode |
| |
| Xian Yuezhong,Xu Jiming,Lu Jiaxing,Liu Meichuan,Cai Qi,Jin Litong. Direct Monitoring of Nitric Oxide Release from Fibrocytes with PVP/Pd/IrO_2/Nation Chemically Modified Microelectrode[J]. Acta Chimica Sinica, 2002, 60(8): 1459-1464 |
| |
| Authors: | Xian Yuezhong Xu Jiming Lu Jiaxing Liu Meichuan Cai Qi Jin Litong |
| |
| Affiliation: | Department of Chemistry, East China Normal University.Shanghai (200062) |
| |
| Abstract: | PVP/Pd/IrO_2/Nafion microsensor was fabricated to measure nitric oxide production in fibrocytes directly. In the experiments, fibrocytes did not release nitric oxide after stimulated with L- arginine and acetylcholine under normal condition. After induced with lipopolysaccharide, NO was produced in high concentration and NO levels were increased after stimulated with L-arginine and acetylcholine. On the other hand, L-N~w-nitro-arginine, an NO synthase inhibitor, decreased the action of L-arginine and acetylcholine. |
| |
| Keywords: | fibrocytes PVP/Pd/IrO 2/Nafion modified electrode nitric oxide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《化学学报》浏览原始摘要信息 |
|
点击此处可从《化学学报》下载全文 |
