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Rapid determination of isocitrate dehydrogenase mutation status of human gliomas by extraction nanoelectrospray using a miniature mass spectrometer |
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| Authors: | Pu Fan Alfaro Clint M. Pirro Valentina Xie Zhuoer Ouyang Zheng Cooks R. Graham |
| Affiliation: | 1.Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA ;2.Department of Precision Instrument, Tsinghua University, Beijing, 100084, China ; |
| Abstract: | Analytical and Bioanalytical Chemistry - Isocitrate dehydrogenase (IDH) I and II mutations in gliomas cause an abnormal accumulation of 2-hydroxyglutarate (2-HG) in these tumor cells. These... |
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