A multivalent probe for AI-2 quorum-sensing receptors |
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Authors: | Garner Amanda L Park Junguk Zakhari Joseph S Lowery Colin A Struss Anjali Kumari Sawada Daisuke Kaufmann Gunnar F Janda Kim D |
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Affiliation: | Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States. |
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Abstract: | Multivalency is a common principle in the recognition of cellular receptors, and multivalent agonists and antagonists have played a major role in understanding mammalian cell receptor biology. The study of bacterial cell receptors using similar approaches, however, has lagged behind. Herein we describe our efforts toward the development of a dendrimer-based multivalent probe for studying AI-2 quorum-sensing receptors. From these studies, we have discovered a chemical probe specific for Lsr-type AI-2 quorum-sensing receptors with the potential for enabling the identification of new bacterial species that utilize AI-2 as a quorum-sensing signaling molecule. |
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