Synthesis of novel heteroaromatics structurally related to ellipticine alkaloids via thermolysis of pyridannulated enyne-carbodiimides |
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| Authors: | Lu Xiaoling Petersen Jeffrey L Wang Kung K |
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| Institution: | Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506-6045, USA. |
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| Abstract: | New synthetic pathways to the 5H-pyrido3',4':4,5]pyrrolo2,3-b]quinolines 6, the 6H-pyrido3',4':4,5]pyrrolo2,3-b]1,6]naphthyridines 7, and the 11H-pyrido4',3':4,5]pyrrolo2,3-b]quinolines 8 via thermolysis of the pyridannulated enyne-carbodiimides 14, 19, and 23 were established. These novel heteroaromatic systems are structurally related to ellipticine alkaloids and could serve as DNA-intercalating agents. |
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