| Study on the Stereoselective Synthesis of Carbapenem Sidechain （2S,4S）-4-Acetylsulphanyl-2- [（S）-l-phenylethylcarbamoyl]- pyrrolidine-l-carboxylic Acid 4-Nitrobenzyl Ester |
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| 作者姓名： | QianLIU GangFANG LiPingWU JianMeiCUI XiaoTianLIANG SongWU |
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| 作者单位： | InstituteofMateriaMedica,PekingUnionMedicalCollege＆ChineseAcademyofMedicalSciences,Beijing100050 |
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| 摘 要： | A stereoselective and economic synthesis of the carbapenem sidechain (2S, 4S)-4-ace-tylsulphanyl-2- (S) 1-phenylethyl-carbamoyl] pyrrolidine-l-carboxylic acid 4-nitrobenzyl ester was developed. Due to the effect of spatial hindrance, only the (2S,4S) diastereomer 3 was obtained by coupling 1 and the inexpensive racemic 2 catalyzed by EEDQ.
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| 关 键 词： | 立体选择性合成 酰化作用 （2S 4S）-4-乙酰硫-2-[（S）-l-苯乙基氨基甲酰]-吡咯-l-羧酸4-硝基苄基酯 EEDQ 催化剂 |
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