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Nickel-Copper-Catalyzed Hydroacylation of Vinylarenes with Acyl Fluorides and Hydrosilanes |
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| Authors: | Yusuke Ueda Dr. Tomohiro Iwai Prof. Dr. Masaya Sawamura |
| Affiliation: | 1. Department of Chemistry, Faculty of Science, Hokkaido University, 060-0810 Sapporo, Japan;2. Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21, Nishi 10, Kita-ku, 001-0021 Sapporo, Japan |
| Abstract: | The hydroacylation of vinylarenes with acyl fluorides and hydrosilanes was enabled by a synergistic bimetallic Ni/Cu-catalytic system, giving access to the corresponding branched ketone products. The reaction takes place under mild conditions at 25–80 °C and tolerates base-sensitive functional groups such as methoxycarbonyl and acetoxy groups. |
| Keywords: | acyl fluorides cooperative catalysis copper hydroacylation nickel |