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Access to Enantiopure Advanced Intermediates en Route to Madangamines |
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| Authors: | Dr Celeste Are Dr Maria Pérez Dr Roberto Ballette Dr Stefano Proto Dr Federica Caso Nihan Yayik Prof Joan Bosch Prof Mercedes Amat |
| Institution: | 1. Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain;2. Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, and Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921 Santa Coloma, de Gramanet, Spain |
| Abstract: | The synthesis of enantiopure ABCE and ABCD tetracyclic advanced intermediates en route to madangamine alkaloids and studies for the construction of the triunsaturated 15-membered D ring of madangamine B and the saturated 13-membered D ring of madangamine E are reported. |
| Keywords: | alkaloids macrocycles madangamines skipped dienes total synthesis |