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15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging |
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| Authors: | Dr. Ivan V. Skovpin Alexandra Svyatova Dr. Nikita Chukanov Prof. Dr. Eduard Y. Chekmenev Dr. Kirill V. Kovtunov Prof. Dr. Igor V. Koptyug |
| Affiliation: | 1. International Tomography Center, SB RAS, 3A Institutskaya st., Novosibirsk, 630090 Russia Novosibirsk State University, 2 Pirogova st., Novosibirsk, 630090 Russia;2. International Tomography Center, SB RAS, 3A Institutskaya st., Novosibirsk, 630090 Russia;3. Department of Chemistry, Karmanos Cancer Institute (KCI), Integrative Biosciences (Ibio), Wayne State University, Detroit, MI USA |
| Abstract: | Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire 15N MR images at natural abundance of the 15N nuclei for the first time. |
| Keywords: | 15N natural abundance hyperpolarization MRI parahydrogen SABRE |