Copper-Photocatalyzed Borylation of Organic Halides under Batch and Continuous-Flow Conditions |
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| Authors: | Dr. Antoine Nitelet Dr. Damien Thevenet Dr. Bruno Schiavi Dr. Christophe Hardouin Dr. Jean Fournier Dr. Rodolphe Tamion Prof. Dr. Xavier Pannecoucke Prof. Dr. Philippe Jubault Prof. Dr. Thomas Poisson |
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| Affiliation: | 1. Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France;2. Industrial Research Centre–, Oril Industrie, CS 60125, 76210 Bolbec, France |
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| Abstract: | The copper-photocatalyzed borylation of aryl, heteroaryl, vinyl and alkyl halides (I and Br) was reported. The reaction proceeded using a new heteroleptic Cu complex under irradiation with blue LEDs, giving the corresponding boronic-acid esters in good to excellent yields. The reaction was extended to continuous-flow conditions to allow an easy scale-up. The mechanism of the reaction was studied and a mechanism based on a reductive quenching (CuI/CuI*/Cu0) was suggested. |
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| Keywords: | borylation continuous flow copper photocatalysis visible light |
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