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Distorted Phthalocyanines by Click Chemistry: Photoacoustic,Photothermal, and Surface-Enhanced Resonance Raman Studies |
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| Authors: | Dr Waqar Rizvi Naxhije Berisha Dr Christopher Farley Dr N V S Dinesh K Bhupathiraju Dr Chrysafis Andreou Emaad Khwaja German V Fuentes Dr Moritz F Kircher Dr Ruomei Gao Dr Charles Michael Drain |
| Institution: | 1. Department of Chemistry, Hunter College of the City University of New York, New York, New York, 10065 USA;2. Department of Radiology, Memorial Sloan Kettering Cancer Center New York, New York, 10065 USA;3. Institute for Cancer Research and Education, SUNY Old Westbury, Old Westbury, New York, 11568 USA |
| Abstract: | Distortion of nominally planar phthalocyanine macrocycles affects the excited state dynamics in that most of the excited-state energy decays through internal conversion. A click-type annulation reaction on a perfluorophthalocyanine platform appending a seven-membered ring to the β-positions on one or more of the isoindoles distorts the macrocycle and modulates solubility. The distorted derivative enables photoacoustic imaging, photothermal effects, and strong surface-enhanced resonance Raman signals. |
| Keywords: | click chemistry photoacoustic imaging photothermal therapy phthalocyanines Raman spectroscopy |