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Directing-Group-Free C7-Alkylations of N-Alkylindoles Mediated by Cationic Zirconium Complexes: Role of Brønsted Acid for Catalytic Manifold |
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| Authors: | Ping Chen Yanhong Hao Xinxin Wang Prof?Dr Dan Yuan Prof?Dr Yingming Yao Prof?Dr Lutz Ackermann |
| Institution: | 1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 P. R. China;2. Institut für Organische und Biomolekulare Chemie, Georg-August-Universiät Götingen, Tammannstraße 2, 37077 Götingen, Germany |
| Abstract: | Highly position selective alkylations of N-alkylindoles at C7-positions have been enabled by cationic zirconium complexes. The strategy provides a straightforward access to install alkyl groups at C7-positions of indoles without a complex directing group. Mechanistic studies provided support for the importance of Brønsted acids in the catalytic manifold. |
| Keywords: | C7-alkylation C?H activation N-alkylindoles organic chemistry zirconium catalyst |