Self-Assembly and Antitumor Activity of a Polyoxovanadate-Based Coordination Nanocage |
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| Authors: | Dr. Yan Zheng Dr. Hongmei Gan Yao Zhao Wanling Li Yuchen Wu Xuechun Yan Yifan Wang Prof. Jinhua Li Prof. Juan Li Prof. Xinlong Wang |
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| Affiliation: | 1. School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, Jilin, 130021 P.R. China Department of Geriatrics, First Hospital of Jilin University, Changchun, Jilin, 130021 P.R. China;2. Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024 P.R. China;3. School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, Jilin, 130021 P.R. China |
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| Abstract: | A new supramolecular nanocage, VMOP- 31 , based on polyoxovanadate as the molecular building block, has been designed and synthesized under solvothermal conditions. The structure of VMOP- 31 was determined by single-crystal and powder X-ray diffraction, FTIR spectroscopy, UV/Vis spectrophotometry, and thermogravimetric analysis. The nanocage exhibits octahedral geometry and is constructed of six {V5O9Cl(COO)4} at the vertices and eight TATB (H3TATB=4,4′,4′′-(s-triazine-2,4,6-triyl)tribenzoic acid) ligands on the faces. Impressively, VMOP- 31 exhibited high efficiency in the inhibition of cell growth of solid tumors, such as human liver cancer cells SMMC-7721, and superior results in the treatment of liver tumors in mice compared with classic cisplatin. Detailed studies revealed that the potential mechanism of cell death induced by VMOP- 31 involves cell cycle arrests, DNA damage, and subsequent apoptosis. Moreover, VMOP- 31 exhibited negligible side effects in the mice compared with cisplatin. To the best of our knowledge, VMOP- 31 is the first supramolecular nanocage applied to hepatic tumors both in vitro and in vivo. |
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| Keywords: | antitumor agents biological activity cage compounds nanostructures polyoxometalates supramolecular chemistry |
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