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Multiple Quantum Coherences Hyperpolarized at Ultra-Low Fields |
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| Authors: | Dr Kai Buckenmaier Prof Dr Klaus Scheffler Dr Markus Plaumann Paul Fehling Prof Dr Johannes Bernarding Dr Matthias Rudolph Dr Christoph Back Prof Dr Dieter Koelle Prof Dr Reinhold Kleiner Prof Dr Jan-Bernd Hövener Dr Andrey N Pravdivtsev |
| Institution: | 1. High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Max-Planck-Ring 11, 72076 Tübingen, Germany;2. High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Max-Planck-Ring 11, 72076 Tübingen, Germany
Department for Biomedical Magnetic Resonance, University of Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany;3. Institute for Biometrics and Medical Informatics, Otto-von-Guericke University Building 02, Leipziger Str. 44, 39120 Magdeburg, Germany;4. High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Max-Planck-Ring 11, 72076 Tübingen, Germany Physikalisches Institut and Center for Quantum Science (CQ) in LISA+, University of Tübingen, Auf der Morgenstelle 14, 72076 Tübingen, Germany;5. Physikalisches Institut and Center for Quantum Science (CQ) in LISA+, University of Tübingen, Auf der Morgenstelle 14, 72076 Tübingen, Germany;6. Section Biomedical Imaging Molecular Imaging North Competence Center (MOIN CC) Department of Radiology and Neuroradiology University Medical Center Kiel, Kiel University, Am Botanischen Garten 14, 24114 Kiel, Germany |
| Abstract: | The development of hyperpolarization technologies enabled several yet exotic NMR applications at low and ultra-low fields (ULF), where without hyperpolarization even the detection of a signal from analytes is a challenge. Herein, we present a method for the simultaneous excitation and observation of homo- and heteronuclear multiple quantum coherences (from zero up to the third-order), which give an additional degree of freedom for ULF NMR experiments, where the chemical shift variation is negligible. The approach is based on heteronuclear correlated spectroscopy (COSY); its combination with a phase-cycling scheme allows the selective observation of multiple quantum coherences of different orders. The nonequilibrium spin state and multiple spin orders are generated by signal amplification by reversible exchange (SABRE) and detected at ULF with a superconducting quantum interference device (SQUID)-based NMR system. |
| Keywords: | hyperpolarization multiple quantum coherence parahydrogen SABRE SQUID |