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Chiral AuI- and AuIII-Isothiourea Complexes: Synthesis,Characterization and Application |
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| Authors: | Dr Danila Gasperini Dr Mark D Greenhalgh Rehan Imad Shezaib Siddiqui Anum Malik Fizza Arshad Prof Muhammad Iqbal Choudhary Prof Abdullah M Al-Majid Dr David B Cordes Prof Alexandra M Z Slawin Prof Steven P Nolan Prof Andrew D Smith |
| Institution: | 1. EaStCHEM, School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST UK;2. H.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270 Pakistan;3. H.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270 Pakistan
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21412 Saudi Arabia;4. Department of Chemistry and Center for Sustainable Chemistry, King Saud University, P.O. Box 2455, Riyadh, 11451 Saudi Arabia |
| Abstract: | During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes. |
| Keywords: | bioinorganic chemistry coordination chemistry gold homogeneous catalysis N ligands |