Structure-Pattern-Based Total Synthesis |
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Authors: | Christa K G Gerlinger Prof?Dr Tanja Gaich |
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Institution: | Institute of Organic Chemistry, University of Konstanz, Universitätsstrasse 10, 78464 Konstanz, Germany |
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Abstract: | In this article the concept of structure-pattern-recognition and its application to total synthesis is summarized. By applying this synthetic strategy to the two biogenetically unrelated natural product families Sarpagine and Stemona alkaloids, a drastic increase of synthetic efficiency could be achieved. To highlight its potential, this strategy is compared with some elegant target-oriented syntheses. The importance of strategic planning and synthesis design is clearly demonstrated. |
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Keywords: | alkaloids biomimetic synthesis cycloadditions natural products synthetic methods |
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