|
|||||
|
|
Zinc-Mediated Intermolecular Reductive Radical Fluoroalkylsulfination of Unsaturated Carbon–Carbon Bonds with Fluoroalkyl Bromides and Sulfur Dioxide |
|
| Authors: | Yongan Liu Qiongzhen Lin Zhiwei Xiao Changge Zheng Prof?Dr Yong Guo Prof?Dr Qing-Yun Chen Prof?Dr Chao Liu |
| Institution: | 1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 P. R. China
These authors contributed equally to this work.;2. School of Chemical Engineering, Xinjiang Agricultural University, Urumqi, Xinjiang Uygur Autonomous Region, 830052 P. R. China These authors contributed equally to this work.;3. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 P. R. China;4. School of Chemical Engineering, Xinjiang Agricultural University, Urumqi, Xinjiang Uygur Autonomous Region, 830052 P. R. China |
| Abstract: | A versatile and general zinc-mediated intermolecular reductive radical fluoroalkylsulfination of unsaturated C?C bonds has been developed using readily available fluoroalkyl bromides and 1,4-diazabicyclo2.2.2]octane-bis(sulfur dioxide) adduct (DABSO) with wide substrate scope and excellent functional group tolerance. Sulfur dioxide anion radical generated in situ from the reduction of sulfur dioxide with zinc may be involved in the reaction mechanism. |
| Keywords: | fluoroalkylsulfination radical reactions reductive sulfur dioxide synthetic methods |