Copper-Catalyzed Enantio- and Diastereoselective Addition of Silicon Nucleophiles to 3,3-Disubstituted Cyclopropenes |
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Authors: | Liangliang Zhang Prof. Dr. Martin Oestreich |
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Affiliation: | Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin, Germany |
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Abstract: | A highly stereocontrolled syn-addition of silicon nucleophiles across cyclopropenes with two different geminal substituents at C3 is reported. Diastereomeric ratios are excellent throughout (d.r.≥98:2) and enantiomeric excesses usually higher than 90 %, even reaching 99 %. This copper-catalyzed C−Si bond formation closes the gap of the direct synthesis of α-chiral cyclopropylsilanes. |
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Keywords: | asymmetric catalysis boron copper silicon strained molecules |
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