Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization |
| |
| Authors: | Jordy M Saya Dr Eelco Ruijter Prof?Dr Romano V A Orru |
| |
| Institution: | Department of Chemistry & Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands |
| |
| Abstract: | Monoterpenoid indole alkaloids are the major class of tryptamine-derived alkaloids found in nature. Together with their structural complexity, this has attracted great interest from synthetic organic chemists. In this Review, the syntheses of Aspidosperma and Strychnos alkaloids through dearomatization of indoles are discussed. |
| |
| Keywords: | alkaloids biomimetic synthesis dearomatization indoles natural product synthesis |
|
|
