Transient and Recyclable Halogenation Coupling (TRHC) for Isoflavonoid Synthesis with Site-Selective Arylation |
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Authors: | Prof. Dr. Jie-Ping Wan Zhi Tu Yuyun Wang |
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Affiliation: | 1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330022 P. R. China;2. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330022 P. R. China These authors contributed equally |
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Abstract: | A transient and recyclable C−H iodination has been designed for the synthesis of isoflavonoids through the domino reactions of o-hydroxyphenyl enaminones and aryl boronic acids in the presence of catalytic KI and Pd catalyst. Instead of the conventional cross-coupling strategy employing pre-halogenated substrates, this method transforms raw C−H bond by means of a transient C−H halogenation to smoothly relay the subsequent C-arylation. Consequently, such a method avoids the pre-functionalization for C−halogen bond installation as well as the generation of stoichiometric halogen-containing waste following the cross-coupled product, disclosing an intriguing new coupling protocol to forge the C−C bond in the virgin area between classical C−X (X=halogen) bond cross coupling and the C−H activation. |
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Keywords: | halogenation isoflavonoids recyclable selective arylation transient |
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