|
|||||
|
|
Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow |
|
| Authors: | Yuchao Deng Xiao-Jing Wei Prof. Xiao Wang Prof. Dr. Yuhan Sun Prof. Dr. Timothy Noël |
| Affiliation: | 1. Department of Chemical Engineering and Chemistry, Micro Flow Chemistry and Synthetic Methodology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands;2. Department of Chemical Engineering and Chemistry, Micro Flow Chemistry and Synthetic Methodology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands These authors contributed equally to this work.;3. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China;4. School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210 P. R. China Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201210 P. R. China |
| Abstract: | Transition-metal-catalyzed cross-coupling chemistry can be regarded as one of the most powerful protocols to construct carbon–carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop protocols that utilize cheaper and more sustainable metal sources. Herein, we report a selective, practical, and fast iron-based cross-coupling reaction that enables the formation of Csp−Csp3 and Csp2−Csp3 bonds. In a telescoped flow process, the reaction can be combined with the Grignard reagent synthesis. Moreover, flow allows the use of a supporting ligand to be avoided without eroding the reaction selectivity. |
| Keywords: | catalysis cross-coupling flow chemistry Grignard reagents iron |