| Affiliation: | 1. Natural Product Chemistry & Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061 HP, India Academy of Scientific & Innovative Research, New Delhi, 110025 India;2. Natural Product Chemistry & Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061 HP, India |
| Abstract: | Polystyrene-supported palladium (Pd@PS) nanoparticles (NPs) have been used to catalyze the aminocarbonylation of aryl halides with amines using oxalic acid as a CO source for the first-time for the synthesis of amides. Furthermore, o-iodoacetophenones participated in amidation and cyclization reactions to give isoindolinones in a single step following a concerted approach. Oxalic acid has been used as a safe, environmentally benign and operationally simple ex situ sustainable CO source under double-layer-vial (DLV) system for different aminocarbonylation reactions. Catalyst stability under a CO environment is a challenging task, however, Pd@PS was found to be recyclable and applicable for a vast substrate scope avoiding regeneration steps. Easy handling of oxalic acid, additive and base-free CO generation, catalyst stability and effortless catalyst separation from the reaction mixture by filtration and introduce of DLV are the added advantages to make the overall process a sustainable approach. |
