Distance-independent Cross-correlated Relaxation and Isotropic Chemical Shift Modulation in Protein Dynamics Studies |
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Authors: | Prof Beat Vögeli Prof Liliya Vugmeyster |
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Institution: | 1. Department of Biochemistry and Molecular Genetics, University of Colorado at Denver, 12801 East 17th Avenue, Aurora, CO, 80045 United States;2. Department of Chemistry, University of Colorado at Denver, 1201 Laurimer Street Denver, CO, 80204 United States |
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Abstract: | Cross-correlated relaxation (CCR) in multiple-quantum coherences differs from other relaxation phenomena in its theoretical ability to be mediated across an infinite distance. The two interfering relaxation mechanisms may be dipolar interactions, chemical shift anisotropies, chemical shift modulations or quadrupolar interactions. These properties make multiple-quantum CCR an attractive probe for structure and dynamics of biomacromolecules not accessible from other measurements. Here, we review the use of multiple-quantum CCR measurements in dynamics studies of proteins. We compile a list of all experiments proposed for CCR rate measurements, provide an overview of the theory with a focus on protein dynamics, and present applications to various protein systems. |
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Keywords: | biomacromolecules correlated motion cross-correlated relaxation multiple-quantum coherence protein dynamics |
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