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Selective Photoinactivation of Methicillin-Resistant Staphylococcus aureus by Highly Positively Charged RuII Complexes |
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| Authors: | Dr. Yang Feng Dr. Wei-Ze Sun Prof. Xue-Song Wang Prof. Qian-Xiong Zhou |
| Affiliation: | 1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190 P.R. China University of Chinese Academy of Sciences, Beijing, 100049 P.R. China;2. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190 P.R. China |
| Abstract: | Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram-positive Staphylococcus aureus (S. aureus), including methicillin-resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents. |
| Keywords: | antimicrobial photodynamic therapy methicillin-resistant Staphylococcus aureus reactive oxygen species ruthenium(II) polypyridyl complexes selectivity |