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Photochemical Alkene Isomerization for the Synthesis of Polysubstituted Furans and Pyrroles under Neutral Conditions |
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| Authors: | Dr. Johannes C. L. Walker Dr. Simon Werrel Prof. Dr. Timothy J. Donohoe |
| Affiliation: | 1. Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA UK These authors contributed equally.;2. Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA UK |
| Abstract: | A photochemical approach to polysubstituted heterocycles using UV-induced alkene isomerization is described. The method allows for the synthesis of disubstituted furans and pyrroles under mild and neutral conditions and also provides access to a class of trisubstituted furans pertinent to natural-product synthesis. The method has broad functional-group tolerance and many richly decorated heterocycles have been prepared incorporating functional groups that are unstable under Brønsted and Lewis acidic conditions. |
| Keywords: | functional-group tolerance furans heterocycles photochemical isomerization pyrroles |