G-SERF Editing in Two-Dimensional Pure-Shift Total Correlation Spectroscopy: Scalar Coupling Measurements for a Group of Spins in Organic Molecules |
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Authors: | Dr. Veera Mohana Rao Kakita Mamata V Joshi Prof. Ramakrishna V Hosur |
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Affiliation: | 1. UM-DAE-Centre for Excellence in Basic Sciences, University of Mumbai, Kalina Campus, Santacruz, Mumbai, 400 098 India;2. Department of Chemical Sciences, Tata Institute of Fundamental Research (TIFR), 1-Homi Bhabha Road, Colaba, Mumbai, 400 005 India |
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Abstract: | A novel G-SERF-PSYCHE-TOCSY (gradient encoded selective refocusing in pure shift yielded by chirp excitation version of total correlation spectroscopy) NMR pulse scheme has been proposed, which produces TOCSY chemical shift correlations, on one hand, and scalar coupling values for the spins scalarly coupled to irradiated resonances, by showing them as doublets along the indirect dimension, on the other. Therefore, recording such an experiment, for a group of spins with overlapping chemical shifts, in organic molecules can adequately provide scalar coupling information in a G-SERF manner along the indirect dimensions, and they can be assigned to particular spin pairs. Such COSY chemical shift correlations (which appear as doublets for the scalarly coupled spins) can be readily discriminated from the TOCSY peaks (which do not show such splitting) in the G-SERF-PSYCHE-TOCSY spectrum. |
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Keywords: | homodecoupling nuclear magnetic resonance organic molecules scalar couplings total correlation spectroscopy |
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