Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals |
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| Authors: | Jia-Bin Han Ao Guo Prof Xiang-Ying Tang |
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| Institution: | Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, 430074 P. R. China |
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| Abstract: | A challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β-fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic studies revealed that the electron-neutral phosphine acts as the deoxygenation reagent. |
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| Keywords: | alkenes alkoxyl radical deoxygenation photoredox catalysis radical alkylation |
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