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Easy Ruthenium-Catalysed Oxidation of Primary Amines to Nitriles under Oxidant-Free Conditions |
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| Authors: | Dr Thierry Achard Julien Egly Michel Sigrist Dr Aline Maisse-François Dr Stéphane Bellemin-Laponnaz |
| Institution: | Département des Matériaux Organiques, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg, CNRS UMR-7504, 23 rue du Loess, BP 43, 67034 Strasbourg Cedex 2, France |
| Abstract: | A dehydrogenation of primary amine to give the corresponding nitrile under oxidant- and base-free conditions catalysed by simple Ru(p-cym)Cl2]2 with no extra ligand is reported. The system is highly selective for alkyl amines, whereas benzylamine derivatives gave the nitrile product together with the imine in a ratio ranging from 14:1 to 4:1 depending on the substrate. Preliminary mechanistic investigations have been performed to identify the key factors that govern the selectivity. |
| Keywords: | acceptorless dehydrogenation dehydrogenation homogenous catalysis nitrile ruthenium |